Many reports outlined adverse effects induced by anti-neoplastic drugs such as cisplatin on renal function even though action mechanism is not yet quite understood. This study aimed at evaluating the effect of cisplastin-based concurrent chemoradiotherapy on glomerular filtration in cervical cancer women. A hospital-based study was carried out from November 2013 to march 2014. Four milliliter of venous blood was collected at four time points (T₀, T₁, T₂ and T₃) prior to the chemotherapy. Creatininemia and creatinine clearance rate were adequately computed. Questionnaire form was administered for documenting the baseline characteristics of participants. Medical records were carefully scrutinized to collect complementary information. A total of 26 women aged more than 21 years old were included in the study with a mean age of 59.34 ± 9.96 years. A significant decreasing the renal function between T₀ and T₁ (p = 0.0076) was observed although thereafter no longer significant between T₁ and T₂ (p = 0.1947) and between T₂ and T₃ (p = 0.1190). This study revealed a cisplatin related damaging and dose-depending effect on renal function and underscores the need for cisplatin dose related adjustment with respect to renal function in medical practice.